Freitag, 29. Juli 2011

1MWP: Dragon with a Flower

The dragon is based on the N-terminal heparin-binding domain of amyloid precursor protein (APP). APP plays a crucial role in the Alzheimer's disease pathogenesis.

Donnerstag, 28. Juli 2011

2OCJ: Pair Skating

This image shows the structure of core domain of protein p53. p53 is a tumor suppressor protein meaning that it has a function in preventing cells from cancer. Because of its role in preventing the genome from mutations, this protein is also referred to as “the guardian of the genome”.

3L1E: Eskimo

AlphaA crystallin is a structure protein which can be found in the eye lens. Alpha crystallin can also act as a chaperon (meaning that it can assist proteins to acquire a certain 3D structure) and prevent the precipitation of denatured proteins. This property is suggested to contribute to the maintenance of lens transparency and to the prevention from cataracts.[
There seems to be a good reason why an Eskimo is shown in this drawing. Interestingly, cataracts and glaucoma are prevalent in Alaska Native people.[

From Protein to Art

Here is an example of how I produce art out of protein molecules.

In this image you see the 2-nd PDZ-domain of the Mint1 protein "Cartoons"-representation, (2) in a "Cartoons"-representation with a reduced ribbon width, and (3) the designed variant of the protein.