The dragon is based on the N-terminal heparin-binding domain of amyloid precursor protein (APP). APP plays a crucial role in the Alzheimer's disease pathogenesis.
Freitag, 29. Juli 2011
Donnerstag, 28. Juli 2011
This image shows the structure of core domain of protein p53. p53 is a tumor suppressor protein meaning that it has a function in preventing cells from cancer. Because of its role in preventing the genome from mutations, this protein is also referred to as “the guardian of the genome”.
AlphaA crystallin is a structure protein which can be found in the eye lens. Alpha crystallin can also act as a chaperon (meaning that it can assist proteins to acquire a certain 3D structure) and prevent the precipitation of denatured proteins. This property is suggested to contribute to the maintenance of lens transparency and to the prevention from cataracts.
There seems to be a good reason why an Eskimo is shown in this drawing. Interestingly, cataracts and glaucoma are prevalent in Alaska Native people.
Here is an example of how I produce art out of protein molecules.
In this image you see the 2-nd PDZ-domain of the Mint1 protein "Cartoons"-representation, (2) in a "Cartoons"-representation with a reduced ribbon width, and (3) the designed variant of the protein.